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Article

The HIF2α-dependent upregulation of SETDB1 facilitates hypoxia-induced functional and phenotypical changes of pulmonary microvascular endothelial cells.

American journal of physiology. Cell physiology - 1 Jan 2025

Zhou Yin, Yang Kai, Zhang Zizhou, Wei Feng, Chen Lishi, Luo Dongling, Yang Ziyang, Zhao Kaixun, Xie Nanshan, Li Wenrui, Liang Shuxin, Xiong Mingmei, Tang Haiyang, Wang Jian, Zhang Caojin

Abstract excerpt

Emerging studies have reported the vital role of histone modification in the dysfunction of pulmonary vascular endothelial cells, which acts as the key reason to drive the hypoxia-induced pulmonary vascular remodeling and pulmonary hypertension (PH). This study aims to investigate the role of a histone 3 lysine 9 (H3K9) methyltransferase, SET domain bifurcated 1 (SETDB1), in hypoxia-induced functional and...

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Share to Basic Helix-Loop-Helix Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39495248
DOI: 10.1152/ajpcell.00732.2023

Genes

SETDB1
SET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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