Preferential binding of HIF-1 to transcriptionally active loci determines cell-type specific response to hypoxia

Abstract excerpt

BACKGROUND: Hypoxia-inducible factor 1 (HIF-1) plays a key role in cellular adaptation to hypoxia. To better understand the determinants of HIF-1 binding and transactivation, we used ChIP-chip and gene expression profiling to define the relationship between the epigenetic landscape, sites of HIF-1 binding, and genes transactivated by hypoxia in two cell lines. RESULTS: We found that when cells were acutely...

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