Article

SET1B drives sustained HIF activity and disease progression in clear cell renal cell carcinoma

2025-05-14

Abstract excerpt

The cellular response to hypoxia is driven by hypoxia-inducible factors (HIFs), which regulate genes involved in glycolysis, angiogenesis, and cell proliferation, as well as inflammation and tumour progression. HIF activation is well-characterised and is primarily regulated by oxygen-dependent prolyl hydroxylation and subsequent degradation. However, how transcription of individual HIF target genes is regulated at...

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Literature Corpus work: 99f94afb-d4e9-5837-8ae0-afa3c9228ac4
DOI: 10.1101/2025.05.13.653699

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