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Fitness Screens Map State-Specific Glioblastoma Stem Cell Vulnerabilities

26 Aug 2024

Abstract excerpt

Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults and is driven by self-renewing glioblastoma stem cells (GSC) that persist after therapy and seed treatment-refractory recurrent tumors. GBM tumors display a high degree of intra- and intertumoral heterogeneity that is a prominent barrier to targeted treatment strategies. This heterogeneity extends to GSCs that exist on a gradient...

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PMID: 39186687
DOI: 10.1158/0008-5472.can-23-4024

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