Article

The functional genomic circuitry of human glioblastoma stem cells

2018-06-28

Abstract excerpt

<h4>Summary</h4> Successful glioblastoma (GBM) therapies have remained elusive due to limitations in understanding mechanisms of growth and survival of the tumorigenic population. Using CRISPR-Cas9 approaches in patient-derived GBM stem cells to interrogate function of the coding genome, we identify diverse actionable pathways responsible for growth that reveal the gene-essential circuitry of GBM stemness. In par...

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Literature Corpus work: 659d9f50-5997-5a50-9d98-67d30e2068b6
DOI: 10.1101/358432

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