Article

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer

2026-03-04

Abstract excerpt

Fibrotic remodeling of tissues and tumors establishes immune-suppressive microenvironments that drive organ dysfunction and, in cancer, limit responses to immunotherapy. Cells exhibiting features of cellular senescence are conserved drivers of fibrotic remodeling and thus represent therapeutic targets, yet senescent states are heterogeneous and can exert both beneficial and pathogenic effects, complicating therape...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1bcb78b2-f17f-501e-a50c-432d73082b33
DOI: 10.64898/2026.03.02.706451

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancerDOI 10.64898/2026.03.02.706451Read

Distinct fibroblast and perivascular senotypes define spatial niches that regulate fibrosisSemantic proximity Read

Senescence Modulation: An Applied Science Review of Strategies in Anti-Aging, Regenerative Aesthetics, and Oncology TherapySemantic proximity Read

Senescence and Immunoregulation in the Tumor MicroenvironmentSemantic proximity Read

Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies.Semantic proximity Read

Transfer learning identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologiesSemantic proximity Read

Senescent cell networks link matrix remodeling and vascular dysfunction in human fibroidsSemantic proximity Read

Decoding senescence of aging single cells at the nexus of biomaterials, microfluidics, and spatial omicsSemantic proximity Read

Targeting senescence‐associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomesSemantic proximity Read

Decoding and Targeting Coordinated CDKN1A and CDKN2A Senescence Programs in ECM-Dominant Cardiovascular PathologiesSemantic proximity Read

Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancerSemantic proximity Read

Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cellsSemantic proximity Read

“Immunomodulatory nanoparticles elicit antifibrotic monocyte activation to resolve murine pulmonary fibrosis”Semantic proximity Read