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Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

1 Jun 2023

Abstract excerpt

The accumulation of senescent cells in the tumor microenvironment can drive tumorigenesis in a paracrine manner through the senescence-associated secretory phenotype (SASP). Using a new p16-FDR mouse line, we show that macrophages and endothelial cells are the predominant senescent cell types in murine KRAS-driven lung tumors. Through single cell transcriptomics, we identify a population of tumor-associated...

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PMID: 37267953
DOI: 10.1016/j.ccell.2023.05.004

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