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Targeting senescence‐associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes

1 Sept 2024

Abstract excerpt

Tumour cell senescence can be induced by various factors, including DNA damage, inflammatory signals, genetic toxins, ionising radiation and nutrient metabolism. The senescence-associated secretory phenotype (SASP), secreted by senescent tumour cells, possesses the capacity to modulate various immune cells, including macrophages, T cells, natural killer cells and myeloid-derived suppressor cells, as well as...

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PMID: 39270064
DOI: 10.1002/ctm2.1772

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