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Article

Senescence and Immunoregulation in the Tumor Microenvironment

7 Oct 2021

Abstract excerpt

Immunotherapies have revolutionized cancer treatment, but despite the many lives that have been extended by these therapies many patients do not respond for reasons that are not well understood. The tumor microenvironment (TME) is comprised of heterogeneous cells that regulate tumor immune responses and likely influence immunotherapy response. Senescent (e.g., aged) stroma within the TME, and its expression of...

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PMID: 34692707
DOI: 10.3389/fcell.2021.754069

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