Article

Sp100A isoform promotes HIRA histone chaperone localization to PML nuclear bodies

2025-03-06

Abstract excerpt

PML nuclear bodies (PML-NBs) are dynamic subnuclear structures important for chromatin dynamics and anti-viral defense. In this study we investigate the role of Sp100 isoforms in promoting localization of the H3.3 histone chaperone HIRA to PML-NBs in human keratinocytes. Sp100 knockout (KO) cell lines were generated using CRISPR-Cas9 technology and shown to display normal keratinocyte differentiation and PML-NB fo...

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Literature Corpus work: 1b8a5e01-214b-529f-a680-3cfa95081b28
DOI: 10.1101/2025.03.06.641437

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