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The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection

22 Mar 2019

Abstract excerpt

Host innate immune defences play a critical role in restricting the intracellular propagation and pathogenesis of invading viral pathogens. Here we show that the histone H3.3 chaperone HIRA (histone cell cycle regulator) associates with promyelocytic leukaemia nuclear bodies (PML-NBs) to stimulate the induction of innate immune defences against herpes simplex virus 1 (HSV-1) infection. Following the activation of...

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PMID: 30901352
DOI: 10.1371/journal.ppat.1007667

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