Article

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

2023-12-21

Abstract excerpt

<h4>Summary</h4> Protein SUMOylation provides a principal driving force for cellular stress responses including DNA-protein crosslink (DPC) repair and arsenic-induced PML body degradation. In genome-scale screens, we identified the human E3 ligase TOPORS as a key effector of SUMO-dependent DPC resolution. We demonstrate that TOPORS promotes DPC repair by functioning as a SUMO-targeted ubiquitin ligase (STUbL) for...

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Literature Corpus work: 8e81a4ce-d68e-5766-a05b-b2b4c279333c
DOI: 10.1101/2023.12.20.572718

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