Article
Splice variants of the nuclear dot-associated Sp100 protein contain homologies to HMG-1 and a human nuclear phosphoprotein-box motif.
Journal of cell science - 1 Mar 1999
Guldner H H, Szostecki C, Schröder P, Matschl U, Jensen K, Lüders C, Will H, Sternsdorf T
Abstract excerpt
Sp100 and PML are interferon-inducible proteins associated with a new class of nuclear domains (known as nuclear dots or PML bodies) which play a role in tumorigenesis, virus infections, and autoimmunity. While PML is extensively alternatively spliced, only two splice variants are known for Sp100...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Animals
- Antigens, Nuclear
- Autoantigens
- Base Sequence
- Carrier Proteins
- Cell Line
- Cloning, Molecular
- Exons
- Gene Expression
- Genetic Variation
- HMGB1 Protein
- HeLa Cells
- High Mobility Group Proteins
- Humans
- Introns
- Molecular Sequence Data