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The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartments

24 Apr 2017

Abstract excerpt

Significance Nuclear domain 10 (ND10) bodies are both sensors and responders to many viruses that infect human cells. The key components of ND10 bodies are PML and SP100. Their importance in innate immune responses to infection is underscored by the observation that numerous viruses have evolved means to degrade, disperse, or at least inactivate PML and SP100. This report focuses on SP100, which, along with PML,...

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PMID: 28439026
DOI: 10.1073/pnas.1703395114

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