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Article

The Speckled Protein (SP) Family: Immunity's Chromatin Readers.

Trends in immunology - 1 Jul 2020

Fraschilla Isabella, Jeffrey Kate L

Abstract excerpt

Chromatin 'readers' are central interpreters of the epigenome that facilitate cell-specific transcriptional programs and are therapeutic targets in cancer and inflammation. The Speckled Protein (SP) family of chromatin 'readers' in humans consists of SP100, SP110, SP140, and SP140L. SPs possess functional domains (SAND, PHD, bromodomain) that dock to DNA or post-translationally modified histones and a caspase...

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Share to Antigens, Nuclear
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32386862
DOI: 10.1016/j.it.2020.04.007
PMCID: PMC8327362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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