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Article

Histone chaperone HIRA regulates neural progenitor cell proliferation and neurogenesis via β-catenin.

The Journal of cell biology - 3 Jul 2017

Li Yanxin, Jiao Jianwei

Abstract excerpt

Histone cell cycle regulator (HIRA) is a histone chaperone and has been identified as an epigenetic regulator. Subsequent studies have provided evidence that HIRA plays key roles in embryonic development, but its function during early neurogenesis remains unknown. Here, we demonstrate that HIRA is enriched in neural progenitor cells, and HIRA knockdown reduces neural progenitor cell proliferation, increases...

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Identifiers

PMID: 28515277
DOI: 10.1083/jcb.201610014
PMCID: PMC5496612

Genes

HIRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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