Article

Cardiac Hemorrhage Precedes Hypertension-induced Fibrosis in Plasminogen Activator Inhibitor-1 Deficient Mice

2025-11-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Aims</h4> Plasminogen activator inhibitor-1 (PAI-1) regulates plasmin-mediated proteolysis, thereby influencing vascular stability and tissue remodeling. Angiotensin II (AngII) induces an increase in PAI-1 during the development of ascending thoracic aortic aneurysm (ATAA). The initial purpose of this study was to determine whether deletion of PAI-1 influenced development of ATAA. Subsequen...

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Literature Corpus work: 1b52cdf3-4313-538c-b40c-40fff4d16db4
DOI: 10.1101/2025.11.19.689269

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