Article

PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hypertension

2023-09-22

Abstract excerpt

<h4>ABSTRACT</h4> Pulmonary arterial hypertension (PAH) is a progressive and potentially a rapidly fatal disease characterized by vasoconstriction and remodeling of small pulmonary arteries (PA) leading to increased pulmonary vascular resistance and right heart failure. Central to the remodeling process is a switch of the smooth muscle cells in small PAs (PASMC) to a proliferative, apoptosis-resistant phenotype....

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Literature Corpus work: e8170ab1-f5eb-5756-8880-47d121e812b6
DOI: 10.1101/2023.09.21.558893

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