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Article

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation.

Scientific reports - 23 Mar 2017

Gupta Kamlesh K, Donahue Deborah L, Sandoval-Cooper Mayra J, Castellino Francis J, Ploplis Victoria A

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1) is known to protect mice against cardiac fibrosis. It has been speculated that PAI-1 may regulate cardiac fibrosis by inactivating urokinase-type plasminogen activator (uPA) and ultimately plasmin (Pm) generation. However, the in vivo role of PAI-1 in inactivating uPA and limiting the generation of Pm during cardiac fibrosis remains to be established. The objective of...

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Identifiers

PMID: 28336948
DOI: 10.1038/s41598-017-00418-y
PMCID: PMC5428408

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