Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Angiotensin II Induces Abdominal Aortic Branch Aneurysms in Fibrillin-1 C1041G/+ Mice-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2026

Franklin Michael K, Howatt Deborah A, Moorleghen Jessica J, Sheppard Mary B, Katsumata Yuriko, Sawada Hisashi, Lu Hong S, Daugherty Alan

Abstract excerpt

BACKGROUND: Mice harboring a missense variant (C1041G) of Fbn1 have been used extensively for aortopathy research, but do not mimic all facets of the human disease. The role of increased AngII (angiotensin II) or blood pressure in determining the arterial phenotype of these mice remains incompletely defined. The purpose of this study was to determine whether AngII, either directly or indirectly through increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines
Share to Angiotensin II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aorta, Thoracic

Share to Aortic Aneurysm, Abdominal

Share to Aortic Dissection

Share to Fibrillin-1

Share to Norepinephrine

Share to X-Ray Microtomography

Source

Open in PubMed Open full text

Identifiers

PMID: 42206371
DOI: 10.1161/ATVBAHA.125.324124
PMCID: PMC13220914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Angiotensin II Induces Abdominal Aortic Branch Aneurysms in Fibrillin-1 C1041G/+ Mice-Brief Report.PMID 42206371Read ↗

Angiotensin II Induces Abdominal Aortic Branch Aneurysms in <i> Fibrillin-1 <sup>C1041G/+</sup> </i> MiceSemantic proximity Read ↗

Deletion of AT1a (Angiotensin II Type 1a) Receptor or Inhibition of Angiotensinogen Synthesis Attenuates Thoracic Aortopathies in Fibrillin1C1041G/+ Mice.Semantic proximity Read ↗

Inhibition of Angiotensin II Dependent AT1a Receptor Stimulation Attenuates Thoracic Aortic Pathology in Fibrillin-1 <sup>C1041G/+</sup> MiceSemantic proximity Read ↗

Pathophysiology of aortic aneurysm: insights from human genetics and mouse models.Semantic proximity Read ↗

Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models.Semantic proximity Read ↗

Numerical knockouts–In silico assessment of factors predisposing to thoracic aortic aneurysmsSemantic proximity Read ↗

Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell levelSemantic proximity Read ↗

Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending AortopathiesSemantic proximity Read ↗

Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice.Semantic proximity Read ↗

Endothelium- and Fibroblast-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Aortic Aneurysm.Semantic proximity Read ↗

Insights on the Pathogenesis of Aneurysm through the Study of Hereditary Aortopathies.Semantic proximity Read ↗

Angiotensin II promotes thoracic aortic dissections and ruptures in Col3a1 haploinsufficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.