Article
Angiotensin II promotes thoracic aortic dissections and ruptures in Col3a1 haploinsufficient mice.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2013
Faugeroux Julie, Nematalla Hany, Li Weiwei, Clement Marc, Robidel Estelle, Frank Michael, Curis Emmanuel, Ait-Oufella Hafid, Caligiuri Giuseppina, Nicoletti Antonino, Hagege Albert, Messas Emmanuel, Bruneval Patrick, Jeunemaitre Xavier, Bergaya Sonia
Abstract excerpt
Vascular Ehlers-Danlos syndrome is a dramatic inherited disease caused by mutations of type III collagen (COL3A1) gene, associated with early-onset occurrence of arterial ruptures. Col3a1(+/-) heterozygous mice, the only vascular Ehlers-Danlos syndrome model available to date, have no spontaneous early vascular phenotype. Our objective was to determine the susceptibility of Col3a1(+/-) mice to develop arterial...
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