Article

Lipoprotein (a) is an Upstream Mediator of Aortic Stenosis

2022-03-30

Abstract excerpt

<h4>Background: </h4> A landmark genome-wide association study has linked mutations in the plasma lipoprotein complex lipoprotein(a) [Lp(a)] and aortic stenosis. We attempted to determine whether Lp(a) is a key upstream mediator of aortic stenosis. <h4>Methods:</h4> Male, Lp(a) transgenic (N=10) and control mice (N=10) were fed a high cholesterol diet for 6 weeks, then hearts were sectioned for histological analys...

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Literature Corpus work: ce138c85-e92f-5619-8009-508ebaf469e7
DOI: 10.22541/au.164864502.22517521/v1

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