Article

Activation of HIF2 leads to vascular remodeling and inflammation, coronary thrombosis and arterial dilation, recapitulating cardiac involvement of Kawasaki disease

2024-01-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> global deletion of Vhl leads to vascular defects and early lethality, precluding the study of VHL/HIF signaling during coronary formation and homeostasis. Hypoxia pathway has been associated with cardiovascular diseases involving inflammation and vascular remodeling like atherosclerosis, but its role in Kawasaki Disease (KD) remains unknown. Coronary dilatation and vessel r...

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Literature Corpus work: b477edbd-2d96-5e20-8c25-72a7659553aa
DOI: 10.1101/2024.01.22.576642

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