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Inhibition of Angiotensin II Dependent AT1a Receptor Stimulation Attenuates Thoracic Aortic Pathology in Fibrillin-1 <sup>C1041G/+</sup> Mice

2020-06-02

Abstract excerpt

<h4>Graphic Abstract</h4> <h4>Objective</h4> A cardinal feature of Marfan syndrome is thoracic aortic aneurysm (TAA). The contribution of ligand-dependent stimulation of angiotensin II receptor type 1a (AT1aR) to TAA progression remains controversial because the beneficial effects of angiotensin receptor blockers have been ascribed to off-target effects. This study used genetic and pharmacologic modes of attenua...

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Literature Corpus work: e475bc86-eaf3-5d12-a99e-54ac7f7a52f7
DOI: 10.1101/2020.06.01.127670

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