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Angiotensin II Induces Abdominal Aortic Branch Aneurysms in <i> Fibrillin-1 <sup>C1041G/+</sup> </i> Mice

2025-11-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Mice harboring a missense variant (C1041G) of fibrillin-1 ( Fbn1 ) have been used extensively for aortopathy research, but do not mimic all facets of the human disease. The role of increased angiotensin II (AngII) or blood pressure in determining the arterial phenotype of these mice remains incompletely defined. The purpose of this study was to determine whether AngII, eit...

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Literature Corpus work: c24700e3-0d28-5a45-a467-b05902a186c6
DOI: 10.1101/2025.11.26.690689

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