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Article

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein.

Stem cell reports - 14 Jul 2015

Ehrlich Marc, Hallmann Anna-Lena, Reinhardt Peter, Araúzo-Bravo Marcos J, Korr Sabrina, Röpke Albrecht, Psathaki Olympia E, Ehling Petra, Meuth Sven G, Oblak Adrian L, Murrell Jill R, Ghetti Bernardino, Zaehres Holm, Schöler Hans R, Sterneckert Jared, Kuhlmann Tanja, Hargus Gunnar

Abstract excerpt

Frontotemporal dementia (FTD) is a frequent form of early-onset dementia and can be caused by mutations in MAPT encoding the microtubule-associated protein TAU. Because of limited availability of neural cells from patients' brains, the underlying mechanisms of neurodegeneration in FTD are poorly understood. Here, we derived induced pluripotent stem cells (iPSCs) from individuals with FTD-associated MAPT mutations...

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Identifiers

PMID: 26143746
DOI: 10.1016/j.stemcr.2015.06.001
PMCID: PMC4618448

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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