Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.

doi:10.1016/j.jalz.2018.05.007

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Article

Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2018

García-León Juan Antonio, Cabrera-Socorro Alfredo, Eggermont Kristel, Swijsen Ann, Terryn Joke, Fazal Raheem, Nami FatemehArefeh, Ordovás Laura, Quiles Ana, Lluis Frederic, Serneels Lutgarde, Wierda Keimpe, Sierksma Annerieke, Kreir Mohamed, Pestana Francisco, Van Damme Philip, De Strooper Bart, Thorrez Lieven, Ebneth Andreas, Verfaillie Catherine M

Abstract excerpt

INTRODUCTION: Tauopathies are neurodegenerative diseases characterized by TAU protein-related pathology, including frontotemporal dementia and Alzheimer's disease among others. Mutant TAU animal models are available, but none of them faithfully recapitulates human pathology and are not suitable for drug screening. METHODS: To create a new in vitro tauopathy model, we generated a footprint-free triple MAPT-mutant...

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PMID: 30036493
DOI: 10.1016/j.jalz.2018.05.007

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MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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