Article

Cultivation, differentiation, and lentiviral transduction of human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons for studying human TAU

2022-12-05

Abstract excerpt

<title>Abstract</title> <p>TAU pathology is a major hallmark of many neurodegenerative diseases summarized under the term tauopathies. In most of these diseases, e.g., Alzheimer’s Disease, the neuronal axonal microtubule-binding TAU protein becomes mislocalized to the somatodendritic compartment. In human disease, this missorting of TAU is accompanied by an abnormally high phosphorylation state of the TAU protein...

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Literature Corpus work: d63abb70-3b5a-5674-aa76-02ce442615d2
DOI: 10.21203/rs.3.pex-2083/v1

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