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Modeling Alzheimer’s Disease by Induced Pluripotent Stem Cells Carrying APP D678H Mutation

20 Sept 2018

Abstract excerpt

Alzheimer's disease (AD), probably caused by abnormal accumulation of β-amyloid (Aβ) and aberrant phosphorylation of tau, is the most common cause of dementia among older people. Generation of patient-specific neurons by induced pluripotent stem cell (iPSC) technology facilitates exploration of the disease features in live human neurons from AD patients. In this study, we generated iPSCs from two familial AD...

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PMID: 30238389
DOI: 10.1007/s12035-018-1336-x

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