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Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?

13 Jan 2023

Abstract excerpt

BACKGROUND: Synaptic dysfunction is a major contributor to Alzheimeŕs disease (AD) pathogenesis in addition to the formation of neuritic β-amyloid plaques and neurofibrillary tangles of hyperphosphorylated Tau protein. However, how these features contribute to synaptic dysfunction and axonal loss remains unclear. While years of considerable effort have been devoted to gaining an improved understanding of this...

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PMID: 36646419
DOI: 10.1016/j.jare.2023.01.006

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