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Article

Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens.

Nature biotechnology - 1 Mar 2025

Walsh Zachary H, Shah Parin, Kothapalli Neeharika, Shah Shivem B, Nikolenyi Gergo, Brodtman D Zack, Leuzzi Giuseppe, Rogava Meri, Mu Michael, Ho Patricia, Abuzaid Sinan, Vasan Neil, AlQuraishi Mohammed, Milner Joshua D, Ciccia Alberto, Melms Johannes C, Izar Benjamin

Abstract excerpt

Single-nucleotide variants (SNVs) in key T cell genes can drive clinical pathologies and could be repurposed to improve cellular cancer immunotherapies. Here, we perform massively parallel base-editing screens to generate thousands of variants at gene loci annotated with known or potential clinical relevance. We discover a broad landscape of putative gain-of-function (GOF) and loss-of-function (LOF) mutations,...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 38783148
DOI: 10.1038/s41587-024-02235-x
PMCID: PMC12488219

Genes

PIK3CD
CD19
AKT1
LCK
RHOA
SOS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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