Article
Base editing screens map mutations affecting interferon-γ signaling in cancer.
Cancer cell - 13 Feb 2023
Coelho Matthew A, Cooper Sarah, Strauss Magdalena E, Karakoc Emre, Bhosle Shriram, Gonçalves Emanuel, Picco Gabriele, Burgold Thomas, Cattaneo Chiara M, Veninga Vivien, Consonni Sarah, Dinçer Cansu, Vieira Sara F, Gibson Freddy, Barthorpe Syd, Hardy Claire, Rein Joel, Thomas Mark, Marioni John, Voest Emile E, Bassett Andrew, Garnett Mathew J
Abstract excerpt
Interferon-γ (IFN-γ) signaling mediates host responses to infection, inflammation and anti-tumor immunity. Mutations in the IFN-γ signaling pathway cause immunological disorders, hematological malignancies, and resistance to immune checkpoint blockade (ICB) in cancer; however, the function of most clinically observed variants remains unknown. Here, we systematically investigate the genetic determinants of IFN-γ...
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