Article

Cross-omic dissection reveals locus-specific heterogeneity and antagonistic pleiotropy between Alzheimer’s disease and type 2 diabetes

2026-03-25

Abstract excerpt

Observational studies associate type 2 diabetes (T2D) with increased dementia risk; however, the specificity of this relationship to Alzheimer’s disease (AD) and its biological basis remains unresolved. We apply an integrative cross-omic framework to dissect genetic links between AD and T2D. Genome-wide analyses reveal a modest positive genetic correlation and robust polygenic sign concordance of AD with T2D. High...

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Literature Corpus work: f05b893e-5a54-5067-af70-79ba6ce48910
DOI: 10.64898/2026.03.23.26349030

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