Article
TriTag: an integrative tool to correlate chromatin dynamics and gene expression in living cells.
Nucleic acids research - 16 Dec 2020
Xu Haiyue, Wang Junyan, Liang Ying, Fu Yujuan, Li Sihui, Huang Jinghan, Xu Heng, Zou Wei, Chen Baohui
Abstract excerpt
A wealth of single-cell imaging studies have contributed novel insights into chromatin organization and gene regulation. However, a comprehensive understanding of spatiotemporal gene regulation requires developing tools to combine multiple monitoring systems in a single study. Here, we report a versatile tag, termed TriTag, which integrates the functional capabilities of CRISPR-Tag (DNA labeling), MS2 aptamer...
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