Article

Spatiotemporal Proteome Remodeling Directs Human Hematopoietic Stem Cells via a Metabolic-Cytoskeletal Axis

2026-06-10

Abstract excerpt

<h4>Summary</h4> Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood and immune cells and are central to transplantation and gene therapies. However, the clinical use of these approaches remains limited due to the functional attrition of HSCs during ex vivo adaptation and expansion in culture. As these transitions are executed at the protein and structural level, the primary drivers of c...

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Literature Corpus work: 0e9fac0f-47f5-59c4-9c31-a0bc4cf5cf8c
DOI: 10.64898/2026.06.08.728414

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