Article
Single-molecule transition-state analysis of RNA folding.
Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003
Bokinsky Gregory, Rueda David, Misra Vinod K, Rhodes Maria M, Gordus Andrew, Babcock Hazen P, Walter Nils G, Zhuang Xiaowei
Abstract excerpt
How RNA molecules fold into functional structures is a problem of great significance given the expanding list of essential cellular RNA enzymes and the increasing number of applications of RNA in biotechnology and medicine. A critical step toward solving the RNA folding problem is the characterization of the associated transition states. This is a challenging task in part because the rugged energy landscape of...
Topics
- Dose-Response Relationship, Drug
- Kinetics
- Magnesium
- Models, Theoretical
- Mutation
- Nepovirus
- Nucleic Acid Conformation
- Poisson Distribution
- Protein Binding
- RNA
- RNA, Catalytic