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Article

Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch.

Nucleic acids research - 1 Feb 2012

Eichhorn Catherine D, Feng Jun, Suddala Krishna C, Walter Nils G, Brooks Charles L, Al-Hashimi Hashim M

Abstract excerpt

Single-stranded RNAs (ssRNAs) are ubiquitous RNA elements that serve diverse functional roles. Much of our understanding of ssRNA conformational behavior is limited to structures in which ssRNA directly engages in tertiary interactions or is recognized by proteins. Little is known about the structural and dynamic behavior of free ssRNAs at atomic resolution. Here, we report the collaborative application of...

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Identifiers

PMID: 22009676
DOI: 10.1093/nar/gkr833
PMCID: PMC3273816

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