Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanical unfolding kinetics of the SRV-1 gag-pro mRNA pseudoknot: possible implications for -1 ribosomal frameshifting stimulation.

Scientific reports - 21 Dec 2016

Zhong Zhensheng, Yang Lixia, Zhang Haiping, Shi Jiahao, Vandana J Jeya, Lam Do Thuy Uyen Ha, Olsthoorn René C L, Lu Lanyuan, Chen Gang

Abstract excerpt

Minus-one ribosomal frameshifting is a translational recoding mechanism widely utilized by many RNA viruses to generate accurate ratios of structural and catalytic proteins. An RNA pseudoknot structure located in the overlapping region of the gag and pro genes of Simian Retrovirus type 1 (SRV-1) stimulates frameshifting. However, the experimental characterization of SRV-1 pseudoknot (un)folding dynamics and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Frameshifting, Ribosomal
Share to Gene Products, gag

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnetic Resonance Spectroscopy

Share to Molecular Dynamics Simulation

Share to Oligonucleotides

Share to Protein Denaturation

Share to Ribosomes

Share to RNA Helicases

Source

Open in PubMed Open full text

Identifiers

PMID: 28000744
DOI: 10.1038/srep39549
PMCID: PMC5175198

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanical unfolding kinetics of the SRV-1 gag-pro mRNA pseudoknot: possible implications for -1 ribosomal frameshifting stimulation.PMID 28000744Read ↗

Characterization of the mechanical unfolding of RNA pseudoknots.Semantic proximity Read ↗

Deciphering the sequence-dependent unfolding pathways of an RNA pseudoknot with steered molecular dynamics.Semantic proximity Read ↗

Coordination of -1 programmed ribosomal frameshifting by transcript and nascent chain features revealed by deep mutational scanning.Semantic proximity Read ↗

Local structural and environmental factors define the efficiency of an RNA pseudoknot involved in programmed ribosomal frameshift process.Semantic proximity Read ↗

A characteristic bent conformation of RNA pseudoknots promotes -1 frameshifting during translation of retroviral RNA.Semantic proximity Read ↗

The role of sequence in altering the unfolding pathway of an RNA pseudoknot: a steered molecular dynamics study.Semantic proximity Read ↗

Functional analysis of the SRV-1 RNA frameshifting pseudoknot.Semantic proximity Read ↗

A loop 2 cytidine-stem 1 minor groove interaction as a positive determinant for pseudoknot-stimulated -1 ribosomal frameshifting.Semantic proximity Read ↗

Modeling the structure of the frameshift-stimulatory pseudoknot in SARS-CoV-2 reveals multiple possible conformersSemantic proximity Read ↗

Mutational analysis of the RNA pseudoknot involved in efficient ribosomal frameshifting in simian retrovirus-1.Semantic proximity Read ↗

Specific mutations in a viral RNA pseudoknot drastically change ribosomal frameshifting efficiency.Semantic proximity Read ↗

Small synthetic molecule-stabilized RNA pseudoknot as an activator for –1 ribosomal frameshiftingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.