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Article

Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus

7 Oct 2021

Abstract excerpt

The 2A protein of Theiler's murine encephalomyelitis virus (TMEV) acts as a switch to stimulate programmed -1 ribosomal frameshifting (PRF) during infection. Here, we present the X-ray crystal structure of TMEV 2A and define how it recognises the stimulatory RNA element. We demonstrate a critical role for bases upstream of the originally predicted stem-loop, providing evidence for a pseudoknot-like conformation...

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PMID: 34751406
DOI: 10.1093/nar/gkab969

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