Article

Elevated TGFβ1 Drives IL4I1⁺ Macrophage–Gal-9 Signaling to Shape Tumor-Specific CD8⁺ T- Cell States in COPD-Associated NSCLC

2026-05-04

Abstract excerpt

<title>Abstract</title> <p>Chronic obstructive pulmonary disease (COPD)-associated non-small cell lung cancer (NSCLC) exhibits distinct responses to immune checkpoint blockade, indicating a unique tumor immune microenvironment. Here, we integrate single-cell transcriptomics and T cell receptor sequencing of tumor, adjacent non-tumor, and blood samples from NSCLC patients, together with spatial transcriptomics and...

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Literature Corpus work: 1aa5975a-09f5-557b-8eda-d4c6fc4a5f89
DOI: 10.21203/rs.3.rs-9365545/v1

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Elevated TGFβ1 Drives IL4I1⁺ Macrophage–Gal-9 Signaling to Shape Tumor-Specific CD8⁺ T- Cell States in COPD-Associated NSCLCDOI 10.21203/rs.3.rs-9365545/v1Read

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