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A machining learning-based prognostic model integrating multi-omics defines LGMN as a lysosomal checkpoint on macrophages with co- expressed myeloid checkpoints TIM-3 and LILRB4 associated with immunotherapy resistance in NSCLC

2026-06-23

Abstract excerpt

<title>Abstract</title> <p>Nonsmall cell lung cancer (NSCLC) remains largely refractory to immune checkpoint inhibitors (ICIs), particularly in EGFRmutant disease. Here we integrate singlecell, spatial, and bulk transcriptomics from multiple independent cohorts to dissect the tumor microenvironment of immunotherapytreated NSCLC, with crosscancer validation in external and other cancer cohorts. We identify a disti...

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Literature Corpus work
f174bda2-d34e-57d7-9ef0-bbf65ca07552
DOI
10.21203/rs.3.rs-10103736/v1
Open publication

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A machining learning-based prognostic model integrating multi-omics defines LGMN as a lysosomal checkpoint on macrophages with co- expressed myeloid checkpoints TIM-3 and LILRB4 associated with immunotherapy resistance in NSCLCDOI 10.21203/rs.3.rs-10103736/v1
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