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Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinoma

2 Aug 2023

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Abstract An immunosuppressive microenvironment enriched with regulatory CD4 + T lymphocytes (Tregs) facilitates the progression of lung adenocarcinoma (LUAD). This study aims to investigate the cellular mechanism underlying the formation of the immunosuppressive microenvironment in LUAD. LUAD samples ( n = 12) and normal lung samples ( n = 3) were obtained from patients with different pathological stages of LUAD....

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PMID: 37532692
DOI: 10.1038/s41419-023-06021-6

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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