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Article

Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma.

Journal for immunotherapy of cancer - 1 Jan 2022

Yang Lei, He Yun-Ting, Dong Song, Wei Xue-Wu, Chen Zhi-Hong, Zhang Bo, Chen Wei-Dong, Yang Xiao-Rong, Wang Fen, Shang Xue-Meng, Zhong Wen-Zhao, Wu Yi-Long, Zhou Qing

Abstract excerpt

BACKGROUNDS: Immunotherapy is less effective in patients with epidermal growth factor receptor (EGFR) mutant non-small-cell lung cancer (NSCLC). Lower programmed cell death-ligand 1 (PD-L1) expression and tumor mutation burden (TMB) are reported to be the underlying mechanism. Being another important factor to affect the efficacy of immunotherapy, tumor microenvironment (TME) characteristics of this subgroup of...

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Identifiers

PMID: 35140113
DOI: 10.1136/jitc-2021-003534
PMCID: PMC8830346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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