Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma.

doi:10.1038/s41467-020-16164-1

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Article

Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma.

Nature communications - 8 May 2020

Kim Nayoung, Kim Hong Kwan, Lee Kyungjong, Hong Yourae, Cho Jong Ho, Choi Jung Won, Lee Jung-Il, Suh Yeon-Lim, Ku Bo Mi, Eum Hye Hyeon, Choi Soyean, Choi Yoon-La, Joung Je-Gun, Park Woong-Yang, Jung Hyun Ae, Sun Jong-Mu, Lee Se-Hoon, Ahn Jin Seok, Park Keunchil, Ahn Myung-Ju, Lee Hae-Ock

Abstract excerpt

Advanced metastatic cancer poses utmost clinical challenges and may present molecular and cellular features distinct from an early-stage cancer. Herein, we present single-cell transcriptome profiling of metastatic lung adenocarcinoma, the most prevalent histological lung cancer type diagnosed at stage IV in over 40% of all cases. From 208,506 cells populating the normal tissues or early to metastatic stage cancer...

Topics

Adaptive Immunity
Adenocarcinoma of Lung
Cell Lineage
Cellular Reprogramming
Disease Progression
Endothelial Cells
Humans
Ligands
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myeloid Cells

Myofibroblasts

Neoplasm Metastasis

Neoplasm Staging

Neovascularization, Pathologic

Phenotype

Receptors, Cell Surface

Sequence Analysis, RNA

Single-Cell Analysis

Source

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Identifiers

PMID: 32385277
DOI: 10.1038/s41467-020-16164-1
PMCID: PMC7210975

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