Article

Characterizing the Dynamics of the Single Cell Tumor Microenvironment and Immune Cell Subpopulations during the Progression of Lung Adenocarcinoma

2023-11-07

Abstract excerpt

<h4>Background: </h4> Lung cancer progression typically involves the transition from atypical adenomatous hyperplasia (AAH) to the invasive adenocarcinoma (IA) stage. The immune status in tumor microenvironment (TME) plays a critical role in governing tumor initiation and progression. Nevertheless, the precise variances in the immune microenvironment among these four states remain uncertain. Methods We employed d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8252de83-c87c-547b-9346-a0605850dbe3
DOI: 10.21203/rs.3.rs-3509740/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterizing the Dynamics of the Single Cell Tumor Microenvironment and Immune Cell Subpopulations during the Progression of Lung AdenocarcinomaDOI 10.21203/rs.3.rs-3509740/v1Read

Landscape and dynamics of single tumor and immune cells in early and advanced‐stage lung adenocarcinomaSemantic proximity Read

Spatial transcriptomics uncovers immune-cell plasticity and dedifferentiation signatures in aggressive lung adenocarcinoma subtypesSemantic proximity Read

Spatiotemporal Profiling Unveiling the Cellular Organization Patterns and Local Protumoral Immune Microenvironment Remodeling in Early Lung Adenocarcinoma ProgressionSemantic proximity Read

Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations.Semantic proximity Read

Up-regulated tumor intrinsic growth potential and decreased immune function orchestrate the evolution of lung adenocarcinomaSemantic proximity Read

Multi-Omics reveals SPP1+ Malignant and CXCR4+ TAM crosstalk predicts immunotherapy response in lung adenocarcinoma cancerSemantic proximity Read

Mechanisms of Progression and Heterogeneity in Multiple Nodules of Lung AdenocarcinomaSemantic proximity Read

Single-Cell Analysis Reveals Spatial Heterogeneity of Immune Cells in Lung AdenocarcinomaSemantic proximity Read

Macrophage heterogeneity and oncogenic mechanisms in lung adenocarcinoma: insights from scRNA-seq analysis and predictive modelingSemantic proximity Read

Single-cell profiling reveals the trajectory of FOLR2-expressing tumor-associated macrophages to regulatory T cells in the progression of lung adenocarcinomaSemantic proximity Read

Single-Cell Transcriptomic Analyses of Tumor Ecosystems and Spatial Architectures in Human Small Cell Lung CancerSemantic proximity Read

Macrophage Heterogeneity and Oncogenic Mechanisms in Lung Adenocarcinoma: Insights from scRNA-seq Analysis and Predictive ModelingSemantic proximity Read