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Article

Phenotype molding of stromal cells in the lung tumor microenvironment.

Nature medicine - 1 Aug 2018

Lambrechts Diether, Wauters Els, Boeckx Bram, Aibar Sara, Nittner David, Burton Oliver, Bassez Ayse, Decaluwé Herbert, Pircher Andreas, Van den Eynde Kathleen, Weynand Birgit, Verbeken Erik, De Leyn Paul, Liston Adrian, Vansteenkiste Johan, Carmeliet Peter, Aerts Stein, Thienpont Bernard

Abstract excerpt

Cancer cells are embedded in the tumor microenvironment (TME), a complex ecosystem of stromal cells. Here, we present a 52,698-cell catalog of the TME transcriptome in human lung tumors at single-cell resolution, validated in independent samples where 40,250 additional cells were sequenced. By comparing with matching non-malignant lung samples, we reveal a highly complex TME that profoundly molds stromal cells....

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PMID: 29988129
DOI: 10.1038/s41591-018-0096-5

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