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Single-Cell Transcriptomics of Immune Cells Reveal Diversity and Exhaustion Signatures in Non-Small-Cell Lung Cancer

6 Jul 2022

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Understanding immune cell phenotypes in the tumor microenvironment (TME) is essential for explaining and predicting progression of non-small cell lung cancer (NSCLC) and its response to immunotherapy. Here we describe the single-cell transcriptomics of CD45 + immune cells from tumors, normal tissues and blood of NSCLC patients. We identified three clusters of immune cells exerting immunosuppressive effects: CD8 +...

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PMID: 35874785
DOI: 10.3389/fimmu.2022.854724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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