Article

Single-Cell RNA Sequencing Reveals Tumor Microenvironment Remodeling after Neoadjuvant Immunotherapy in Non-small Cell Lung Cancer

2021-10-07

Abstract excerpt

<title>Abstract</title> <p>Immunotherapy has revolutionized cancer treatment, but most patients are refractory to immunotherapy or acquire resistance. To explore immunotherapy resistance mechanisms, we characterized the transcriptomes of ~92000 single cells from 15 patients with non-small cell lung cancer (NSCLC) during neoadjuvant PD-1 blockade combined with chemotherapy. CD8+ T, natural killer, B, and dendritic...

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Literature Corpus work: f1353310-436c-5bd4-8216-2aa6dcac6a6e
DOI: 10.21203/rs.3.rs-934132/v1

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