Article

Transcription factor regulation as a mechanism of confounding effects between distinct human traits

2015-11-25

Abstract excerpt

Genome-wide association studies (GWAS) to date have discovered thousands of genetic variants linked to human diseases and traits, which hold the potential to unravel the mechanisms of complex phenotypes. However, given that the majority of these associated variants reside in non-coding genomic regions, their predicted cis and trans -regulatory functions remain largely undefined. Here we show that correlation bet...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a844c50-13a3-50b7-a5fb-da02f4fa7eea
DOI: 10.12688/f1000research.7336.1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcription factor regulation as a mechanism of confounding effects between distinct human traitsDOI 10.12688/f1000research.7336.1Read

The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes.Semantic proximity Read

The role of transcription factor 7‐like 2 in metabolic disordersSemantic proximity Read

The TCF7L2 Locus: A Genetic Window Into the Pathogenesis of Type 1 and Type 2 DiabetesSemantic proximity Read

TCF7L2 plays a complex role in human adipose progenitor biology which may contribute to genetic susceptibility to type 2 diabetesSemantic proximity Read

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.Semantic proximity Read

Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.Semantic proximity Read

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.Semantic proximity Read

TCF7L2 plays a complex role in human adipose progenitor biology, which might contribute to genetic susceptibility to type 2 diabetes.Semantic proximity Read

Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes.Semantic proximity Read

Genetic variation at the FTO locus influences RBL2 gene expression.Semantic proximity Read

Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent.Semantic proximity Read

Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism.Semantic proximity Read