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Article

The broad pathogenetic role of TCF7L2 in human diseases beyond type 2 diabetes.

Journal of cellular physiology - 1 Jan 2022

Del Bosque-Plata Laura, Hernández-Cortés Eduardo Pavel, Gragnoli Claudia

Abstract excerpt

The TCF7L2 protein is a key transcriptional effector of the Wnt/β-catenin signaling pathway, regulating gene expression. It was initially identified in cancer research and embryologic developmental studies. Later, the TCF7L2 gene was linked to type 2 diabetes (T2D), implicating TCF7L2 and Wnt-signaling in metabolic disorders and homeostasis. In fact, TCF7L2-T2D variants confer the greatest relative risk for T2D,...

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Share to Diabetes Mellitus, Type 2
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Glucose Intolerance

Share to Polymorphism, Single Nucleotide

Share to Transcription Factor 7-Like 2 Protein

Source

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Identifiers

PMID: 34612510
DOI: 10.1002/jcp.30581
PMCID: PMC9292842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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